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Promethazine with Codeine Oral Remedy contains promethazine, a phenothiazine. Phenothiazines are linked to dystonic reactions, especially in pediatric clients who've an acute sickness linked to dehydration.
Promethazine HCl may very well be applied by itself or as an adjunct to narcotic analgesics all through labor (see DOSAGE AND ADMINISTRATION). Restricted knowledge recommend that use of Promethazine during labor and shipping does not have an appreciable effect on the length of labor or shipping and delivery and would not increase the danger of will need for intervention during the new child.
Pediatric Use of Promethazine VC with codeine oral liquid in small children and Promethazine, phenylephrine, and codeine oral Option in children more youthful than twelve many years of age just isn't proposed. It should not be employed To ease ache immediately after operation to eliminate tonsils or adenoids in any youngsters. Significant breathing problems and deaths are actually documented in certain youngsters who been given codeine right after tonsil or adenoid surgical procedure. Geriatric Proper scientific tests executed to date haven't shown geriatric-precise problems that will limit the usefulness of codeine, phenylephrine, and promethazine mix during the elderly.
The dose you’ll take will depend upon The explanation that you simply’re getting Phenergan (no matter if it’s for nausea and vomiting, allergy symptoms, or as a sedative). To choose Phenergan, you should:
Long-term animal research have not been performed to assess the carcinogenic opportunity of Promethazine, nor are there other animal or human information regarding carcinogenicity, mutagenicity, or impairment of fertility with this particular drug. Promethazine was nonmutagenic within the Salmonella check technique of Ames.
If a youngster has taken codeine or tramadol and you recognize any signs of click here sluggish or shallow respiration, hard or noisy respiratory, confusion, or uncommon sleepiness in a youngster of any age, request professional medical consideration immediately by using the child to an unexpected emergency space or contacting 911.
Codeine has lower plasma protein binding with about here 7 to 25% of codeine sure to plasma proteins. Codeine passes the blood Mind barrier plus the placental barrier. Little amounts of codeine and its metabolite, morphine, are transferred to human breast milk.
Promethazine HCl Oral Remedy is contraindicated in comatose states, As well as in people today acknowledged to become hypersensitive or to obtain had an idiosyncratic response more info to Promethazine or to other phenothiazines.
It is critical that your physician Look at your progress at regular visits to be certain this medication is Operating correctly. Blood checks could be needed to check for unwanted consequences .
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Dosing errors can result in accidental overdose read more and death. To reduce the risk of overdose and respiratory despair, ensure that the dose of Promethazine with Codeine Oral Solution is communicated clearly and dispensed correctly [see Dosage and Administration ( 2.1) ]. Recommend people to normally use an exact milliliter measuring product when measuring and administering Promethazine with Codeine Oral Remedy. Tell patients that household teaspoon is not really an precise measuring unit and this sort of use could lead to overdosage and serious adverse reactions [see ]. For prescriptions where by a measuring product is just not offered, a pharmacist can offer an acceptable calibrated measuring device and can provide Guidelines for measuring the correct dose.
Promethazine with Codeine Oral Resolution may perhaps result in critical hypotension such as orthostatic hypotension and syncope in ambulatory sufferers. There is increased threat in clients whose ability to maintain blood pressure has previously been compromised by a lessened blood quantity or concurrent administration of selected CNS depressant medicines (eg.
Caregivers and sufferers really should often browse the label on prescription bottles to determine if a drugs is made up of codeine or tramadol. You can also question here your son or daughter’s wellness treatment company or a pharmacist. Look at intently for signs of respiration complications in a baby of any age that is having these medicines or in infants subjected to codeine or tramadol by breastmilk.